PDPN marks a subset of aggressive and radiation-resistant glioblastoma cells

PDPN marks a subset of aggressive and radiation-resistant glioblastoma cells

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Treatment-resistant glioma stem cells are thought to propagate and drive growth of malignant gliomas, but their markers and our ability to target them specifically are not well understood.We demonstrate that podoplanin (PDPN) expression is an independent prognostic marker in gliomas across multiple independent anodized pearl price xbox patient cohorts comprising both high- and low-grade gliomas.Knockdown of PDPN radiosensitized glioma cell lines and glioma-stem-like cells (GSCs).Clonogenic assays and xenograft experiments revealed that PDPN expression was associated with radiotherapy resistance and tumor aggressiveness.We further demonstrate that knockdown of PDPN in GSCs in vivo is sufficient to improve overall survival in an intracranial xenograft mouse model.

PDPN therefore identifies a 1950s candy box subset of aggressive, treatment-resistant glioma cells responsible for radiation resistance and may serve as a novel therapeutic target.